Molecule Information

General Information of the Molecule (ID: Mol02185)

• Name: FAS antisense RNA 1 (FAS-AS1) ,Homo sapiens
• Synonyms: FAS-AS1
• Molecule Type: LncRNA
• Gene Name: FAS-AS1
• Gene ID: 100302740
• HGNC ID: HGNC:37128

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydroquinone

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Acute lymphocytic leukemia [1]

• Resistant Disease: Acute lymphocytic leukemia [ICD-11: 2B33.0]
• Resistant Drug: Hydroquinone
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: TK6 cells; Spleen; Homo sapiens (Human); CVCL_0561
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; Knockdown assay; Overexpression assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Aken together, these observations demonstrate crosstalk between FAS-AS1 and DNMT3b via a mutual inhibition loop and indicate a new mechanism by which FAS-AS1 regulates the expression of FAS in benzene-related carcinogenesis.

References

• Ref 1: Regulatory loop between lncRNA FAS-AS1 and DNMT3b controls FAS expression in hydroquinone-treated TK6 cells and benzene-exposed workersEnviron Pollut. 2020 Jun;261:114147. doi: 10.1016/j.envpol.2020.114147. Epub 2020 Feb 11.