Molecule Information

General Information of the Molecule (ID: Mol02180)

• Name: COX2 (COX2) ,Mus musculus
• Synonyms: COX2
• Molecule Type: LncRNA
• Gene Name: COX2
• Gene ID: 5912281
• Ensembl ID: ENSMUSG00000032487

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Carbon tetrachloride

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Liver diseases [1]

• Resistant Disease: Liver diseases [ICD-11: DB90-DB9Z]
• Resistant Drug: Carbon tetrachloride
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Male BALB/c nude mice model; Mus musculus
• Mechanism Description: Expression of COX-2 and LncRNA-COX-2 increased with the progression of liver fibrosis. LncRNA-COX-2 may potentially be considered as a novel therapeutic target for liver fibrosis.

References

• Ref 1: Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachlorideMol Med Rep. 2017 Apr;15(4):1507-1512. doi: 10.3892/mmr.2017.6161. Epub 2017 Feb 2.