Molecule Information

General Information of the Molecule (ID: Mol02176)

• Name: Taurine up-regulated 1 (TUG1) ,Mus musculus
• Synonyms: Tug1
• Molecule Type: LncRNA
• Gene Name: Tug1
• Gene ID: 544752
• Location: chr11:3,589,785-3,599,673[-]
• Ensembl ID: ENSMUSG00000056579

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Myocardial infarction [1]

• Resistant Disease: Myocardial infarction [ICD-11: BA41.0]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• Cell Pathway Regulation: miR-9/KLF5 signaling pathway; Inhibition; hsa05206
• Experiment for Molecule Alteration: Luciferase assay; Knockdown assay; Overexpression assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5.

References

• Ref 1: The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5Cell Death Dis. 2019 Dec 2;10(12):908. doi: 10.1038/s41419-019-2138-4.