Molecule Information

General Information of the Molecule (ID: Mol02175)

Name	Growth arrest associated LncRNA 1 (GASAL1) ,Homo sapiens
Synonyms	GASAL1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	GASAL1
Gene ID	401472
HGNC ID	HGNC:53461
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Hydrogen peroxide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Chronic heart failure [ICD-11: BD10.2]				[1]
Resistant Disease	Chronic heart failure [ICD-11: BD10.2]			Disease Info
Resistant Drug	Hydrogen peroxide			Drug Info
Molecule Alteration	Down-regulation		Expression
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	AC16 cells	Heart	Homo sapiens (Human)	CVCL_4U18
Experiment for Molecule Alteration	ELISA assay; qRT-PCR; Western bloting analysis; Overexpression assay
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis.

References

Ref 1	LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosisCell Mol Biol Lett. 2019 Jun 13;24:41. doi: 10.1186/s11658-019-0165-x. eCollection 2019.

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