Molecule Information

General Information of the Molecule (ID: Mol02175)

• Name: Growth arrest associated LncRNA 1 (GASAL1) ,Homo sapiens
• Synonyms: GASAL1
• Molecule Type: LncRNA
• Gene Name: GASAL1
• Gene ID: 401472
• HGNC ID: HGNC:53461

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Chronic heart failure [1]

• Resistant Disease: Chronic heart failure [ICD-11: BD10.2]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: AC16 cells; Heart; Homo sapiens (Human); CVCL_4U18
• Experiment for Molecule Alteration: ELISA assay; qRT-PCR; Western bloting analysis; Overexpression assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis.

References

• Ref 1: LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosisCell Mol Biol Lett. 2019 Jun 13;24:41. doi: 10.1186/s11658-019-0165-x. eCollection 2019.