Molecule Information

General Information of the Molecule (ID: Mol02170)

• Name: Peptidylprolyl isomerase F (cyclophilin F) (Ppif) ,Mus musculus
• Synonyms: Ppif
• Molecule Type: LncRNA
• Gene Name: Ppif
• Gene ID: 105675
• Location: chr14:25,694,578-25,700,892[+]
• Ensembl ID: ENSMUSG00000021868

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Protirelin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Oxidative stress-related liver diseases [1]

• Resistant Disease: Oxidative stress-related liver diseases [ICD-11: DB90-DB9Z]
• Resistant Drug: Protirelin
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Tshr -/- mice model; Mus musculus
• Experiment for Molecule Alteration: Microarray assay; qRT-PCR; ELISA assay; Western bloting analysis
• Mechanism Description: TSH stimulates hepatic CypD acetylation through the LncRNA-AK044604/SIRT1/SIRT3 signaling pathway, indicating an essential role for TSH in mitochondrial stress in the liver.

References

• Ref 1: Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D AcetylationOxid Med Cell Longev. 2020 Jan 6;2020:1249630. doi: 10.1155/2020/1249630. eCollection 2020.