Molecule Information

General Information of the Molecule (ID: Mol02167)

• Name: Growth arrest specific 5 (GAS5) ,Rattus norvegicus
• Synonyms: Gas5
• Molecule Type: LncRNA
• Gene Name: Gas5
• Gene ID: 81714

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Streptozocin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Chronic kidney disease [1]

• Resistant Disease: Chronic kidney disease [ICD-11: GB61.0]
• Resistant Drug: Streptozocin
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Renal tubular epithelial cells; N.A.; .; N.A.
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Overexpression assay; RIP experiments assay; RNA pull down assay; ChIP assay
• Mechanism Description: Long noncoding RNA growth arrest-specific transcript 5 alleviates renal fibrosis in diabetic nephropathy by downregulating matrix metalloproteinase 9 through recruitment of enhancer of zeste homolog 2.

References

• Ref 1: Long noncoding RNA growth arrest-specific transcript 5 alleviates renal fibrosis in diabetic nephropathy by downregulating matrix metalloproteinase 9 through recruitment of enhancer of zeste homolog 2FASEB J. 2020 Feb;34(2):2703-2714. doi: 10.1096/fj.201901380RR. Epub 2020 Jan 9.