Molecule Information

General Information of the Molecule (ID: Mol02161)

• Name: Maternally expressed 3 (MEG3) ,Mus musculus
• Synonyms: Meg3
• Molecule Type: LncRNA
• Gene Name: Meg3
• Gene ID: 17263
• Location: chr12:109,506,879-109,538,165[+]
• Ensembl ID: ENSMUSG00000021268

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Chembl2042164

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Myocardial infarction [1]

• Resistant Disease: Myocardial infarction [ICD-11: BA41.0]
• Resistant Drug: Chembl2042164
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Primary neonatal mice ventricular myocytes; N.A.; .; N.A.
• In Vivo Model: C57/BL6J mice myocardial infarction model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; Knockdown assay
• Mechanism Description: Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction.

References

• Ref 1: Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarctionJ Cell Mol Med. 2019 Dec;23(12):8369-8380. doi: 10.1111/jcmm.14714. Epub 2019 Oct 20.