Molecule Information

General Information of the Molecule (ID: Mol02152)

• Name: hsa_circRNA_0000309 ,Homo sapiens
• Synonyms: hsa_circRNA_0000309
• Molecule Type: Circular RNA
• Gene Name: hsa_circRNA_0000309

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Germacrone

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Diabetic nephropathy [1]

• Resistant Disease: Diabetic nephropathy [ICD-11: GB61.Z]
• Resistant Drug: Germacrone
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MPC5 cells; Kidney; Mus musculus (Mouse); CVCL_AS87
• In Vivo Model: C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Mechanism Description: Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.

Disease Class: Diabetic nephropathy [1]

• Resistant Disease: Diabetic nephropathy [ICD-11: GB61.Z]
• Resistant Drug: Germacrone
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MPC5 cells; Kidney; Mus musculus (Mouse); CVCL_AS87
• In Vivo Model: C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Mechanism Description: Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.

References

• Ref 1: A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis .Antioxid Redox Signal. 2022 Apr;36(10-12):740-759. doi: 10.1089/ars.2021.0063. 10.1089/ars.2021.0063