Molecule Information

General Information of the Molecule (ID: Mol02112)

• Name: Ribonucleic Acid Polymerase (RNAP) ,Escherichia coli
• Synonyms: RNAP+K265
• Molecule Type: Protein
• Gene Name: RNAP

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: 91347
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rifamycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Mycobacterium abscessus infection [1]

• Resistant Disease: Mycobacterium abscessus infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Rifamycin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SOSP-9607 cells; Bones; Homo sapiens (Human); CVCL_4V80
• Experiment for Molecule Alteration: In vitro rifampicin ADP-ribosyl transferase activity assay; Rifampicin ADP-ribosyl transferase disk assay; Rifampicin ADP-ribosyl transferase MIC assay
• Mechanism Description: Rifamycin resistance is usually associated with mutations in RNAP that preclude rifamycin binding.

References

• Ref 1: Kanglemycin A Can Overcome Rifamycin Resistance Caused by ADP-Ribosylation by Arr Protein .Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0086421. doi: 10.1128/AAC.00864-21. Epub 2021 Oct 4. 10.1128/AAC.00864-21