Molecule Information

General Information of the Molecule (ID: Mol02109)

• Name: (Na+)-NQR maturation NqrM (nqrM) ,Vibrio alginolyticus
• Synonyms: (Na+)-NQR maturation NqrM; nqrM; AOG25_00280; F0254_11835; HKB35_09295; HUO05_09255
• Molecule Type: Protein
• Gene Name: nqrM
• Gene ID: 61533190
• Sequence:
  MNTFLITFAVFVAVITAMAVGYIFQKKVVKGSCGGLGAVGIEKVCNCPEPCDARKKREAR
  EAARAEKLAAWEKDRIA
• Uniprot ID: A0A0H0YCL5_VIBAL

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio alginolyticus

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Balofloxacin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Vibrio alginolyticus infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Vibrio alginolyticus infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Balofloxacin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• Experiment for Molecule Alteration: Western blot analysis
• Mechanism Description: Na(+)-NQR is a membrane-embedded NADH dehydrogenase. Down-regulation of the Na(+)-NQR is required for V. alginolyticus in resistance to BLFX. It is known that the resistant mechanisms of a quinolone antibiotic are through the inhibition of DNA-gyrase which is required for DNA synthesis, and expressional changes of OM proteins which elevate pump activity and decrease OM permeability.

References

• Ref 1: Downregulation of Na(+)-NQR complex is essential for Vibrio alginolyticus in resistance to balofloxacin .J Proteomics. 2012 May 17;75(9):2638-48. doi: 10.1016/j.jprot.2012.03.006. Epub 2012 Mar 17. 10.1016/j.jprot.2012.03.006