Molecule Information

General Information of the Molecule (ID: Mol02105)

• Name: Glycosyltransferase Bme (BME) ,Bacteroides fragilis
• Synonyms: BME
• Molecule Type: Protein
• Gene Name: BME

Kingdom: N.A.
Phylum: Bacteroidetes
Class: Bacteroidia
Order: 171549
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Metronidazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacillus clausii infection [1]

• Resistant Disease: Bacillus clausii infection [ICD-11: 1C4Y.1]
• Resistant Drug: Metronidazole
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Vero cells; Kidney; Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus); CVCL_0059
• Mechanism Description: E. coli mutants lacking the ability to reduce nitrate and chlorate, presumably reducing the rate of metronidazole uptake, are also resistant. A reduced growth rate is also associated with metronidazole resistance in C. perfringens, C. difficile and B. fragilis. Bacteroides resistance-nodulation-division (RND) efflux pumps (bme) also reduce susceptibility to metronidazole.

References

• Ref 1: Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms .J Antimicrob Chemother. 2018 Feb 1;73(2):265-279. doi: 10.1093/jac/dkx351. 10.1093/jac/dkx351