Molecule Information

General Information of the Molecule (ID: Mol02081)

Name	Cysteine desulfurase (K13) ,Plasmodium falciparum
Synonyms	K13 Click to Show/Hide
Molecule Type	Protein
Gene Name	K13
Sequence	MKFLQIIKHLKLQNKKNALDNFVNCRTYEHISNINKLFLNNFSSTKEHSEHGQVKHENFL NNTLQYGENSQNGSTNNLKNGKYNMYVSEGNVNINEEKYKDNNISSNNTQYNNNSSNSGS LNDEGPLWKEHIDDVVNENKKKKMNRFYLDSQATTMIDPRVLDKMLPYMTYIYGNAHSRN HFFGWESEKAVEDARTNLLNLINGKNNKEIIFTSGATESNNLALIGICTYYNKLNKQKNH IITSQIEHKCILQTCRFLQTKGFEVTYLKPDTNGLVKLDDIKNSIKDNTIMASFIFVNNE IGVIQDIENIGNLCKEKNILFHTDASQAAGKVPIDVQKMNIDLMSMSGHKLYGPKGIGAL YIKRKKPNIRLNALIHGGGQERGLRSGTLPTHLIVGFGEAAKVCSLEMNRDEKKVRYFFN YVKDYLTKHLDYIVFNGCQINRYYGNMNISFLFVEGESLLMSLNEIALSSGSACTSSTLE PSYVLRSIGISEDIAHTSIRIGFNRFTTFFEVQQLCINLVKSVERLRSISPLYEME Click to Show/Hide
Uniprot ID	A0A5J6C8W8_PLAFA
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Apicomplexa Class: Aconoidasida Order: Haemosporida Family: Plasmodiidae Genus: Plasmodium Species: Plasmodium falciparum

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Artesunate

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Plasmodium falciparum malaria [ICD-11: 1F40.1]				[1]
Resistant Disease	Plasmodium falciparum malaria [ICD-11: 1F40.1]			Disease Info
Resistant Drug	Artesunate			Drug Info
Molecule Alteration	Missense mutation		p.C580Y
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Red blood cells	Blood	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Whole genome sequencing assay
Experiment for Drug Resistance	Giemsa stain assay
Mechanism Description	All 63 isolates had the K13(C580Y) marker for artemisinin resistance; 79.4% (50/63) had Pfpm2 amplification. K13 mutations confer artemisinin resistance by dampening hemoglobin endocytosis.

References

Ref 1	Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia .Clin Infect Dis. 2021 Aug 2;73(3):406-413. doi: 10.1093/cid/ciaa628. 10.1093/cid/ciaa628