Molecule Information

General Information of the Molecule (ID: Mol02019)

• Name: ATP binding cassette subfamily G member 4 (ABCG4) ,Mycobacteroides abscessus
• Synonyms: ABCG4; LPMP_150900
• Molecule Type: Protein
• Gene Name: ABCG4
• Gene ID: 22573510
• Sequence:
  MGKQVDQVYNPSARTLTPPLRETSEQVALRNTPVDTTDALAMPPLSESDGKDTKVPTCSR
  AVNFTWENLTYQVPVEDKDGNVTYKTLLFNLSGCAKGGRVLAIMGPSGAGKTTLMGTITG
  KLYNATARQEGCCFMNNNIYQQRYKRLVSYVCQDDIVMGKDTPREAIFFSARLRLGLDSS
  TARRRTADVIKRLSLTRCQDTILGIPGILKGVSGGERKRTNIGTELITNPFVMLLDEPTT
  GLDSVNAVRVGQLLQDLAKNDMRTVIATVHSPSSELFDLFDDLLLLAKGHVIYHGPTADS
  IEYFASLGYDVPPRTNPTEYFMNLLQLPEDILSQLWLAWEDYVMSDAARYNPCLTPVTGA
  ITLTDDYLEEQLELKGASFCLQFSELFKRSWRMYLRDPGNFYGRSVQTLFFAIFLGLFFF
  NVQLNQQGVQDRQGALYMTLMNNLFGAAMNGIAAFPPERAVFLQEQANDAYNAYTYFLAK
  NAAELPWQILFPTLFDLIAYFLIHFHRSADAFFVHWFILVLLANLGYAFGLMFATFFKQS
  QAAFAMVPLILLPLFIVAGLFASTDRLYPYWVWLNYLSFPRHAYLGVFTNEFERLTVICS
  PVTPLCTFPDGQSVIEHMGFQNWRYWQSFIALIVYQIGLRFIGATSLFFQGRKRRGKLQF
  VKNLRHRVASPRAIASARSNDVLSDVQSTLVGSIATPSNAYGAETSLRDHQEPHHSLWGN
  EIELAALSPLDTPVTFEESPISVREKKHRY
• Uniprot ID: A0A088RLA3_9TRYP
• HGNC ID: HGNC:13884

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacteroides
Species: Mycobacteroides abscessus

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Miltefosine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Leishmaniasis [1]

• Resistant Disease: Leishmaniasis [ICD-11: 1F54.1]
• Resistant Drug: Miltefosine
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• Mechanism Description: In addition, the overexpression of ABC transporters ABCB4(MDR1), ABCG4, and ABCG6 has also been described to be associated with an increased resistance to several alkyl-lysophospholipids analogues, including MIL in Leishmania, due to a reduced intracellular accumulation because of increased efflux of the drug across the plasma membrane.

References

• Ref 1: Drug resistance and treatment failure in leishmaniasis: A 21st century challenge .PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052. doi: 10.1371/journal.pntd.0006052. eCollection 2017 Dec. 10.1371/journal.pntd.0006052