Molecule Information

General Information of the Molecule (ID: Mol02014)

• Name: Multidrug resistance protein MdtE (MDTE) ,Trichomonas vaginalis
• Synonyms: TVAG_572140
• Molecule Type: Protein
• Gene Name: MDTE
• Gene ID: 4741312
• Sequence:
  MSNNIKLVVVGDGAVGKTCLLVVYARNEFPSEYVPTVFDNYTAKVKIDDTLYPVQLWDTA
  GQEELENIRTLSYQNTSVFLLCFSVTTPTTFDNLTTVWIPEIKRYVKNPEILLIGTKADL
  RNDEQTLKNLEADGKAPITLEQAQQKAKEIGAIAYCECSALKNEGVREAFDKAINHIIEK
  DNGGCCHLI
• Uniprot ID: A2GGN6_TRIVA

Kingdom: N.A.
Phylum: Parabasalia
Class: .
Order: Trichomonadida
Family: Trichomonadidae
Genus: Trichomonas
Species: Trichomonas vaginalis

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Metronidazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Trichomoniasis [1]

• Resistant Disease: Trichomoniasis [ICD-11: 1A92.0]
• Resistant Drug: Metronidazole
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Trichomonas vaginalis ATCC 30001; 5722
• In Vitro Model: Trichomonas vaginalis ATCC 30236; 5722
• In Vitro Model: Trichomonas vaginalis ATCC50148; 5722
• In Vitro Model: Trichomonas vaginalis ATCC 50142; 5722
• In Vitro Model: Trichomonas vaginalis ATCC 50143; 5722
• In Vitro Model: Trichomonas vaginalis ATCC 30238; 5722
• Experiment for Molecule Alteration: Gene sequencing assay
• Experiment for Drug Resistance: Trypan blue exclusion assay
• Mechanism Description: Comparative transcriptomes analysis identified that several putative drug-resistant genes were exclusively upregulated in different MTZ-R strains, such as ATP-binding cassette (ABC) transporters and multidrug resistance pumps.

References

• Ref 1: Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death .Biomedicines. 2021 Dec 2;9(12):1817. doi: 10.3390/biomedicines9121817. 10.3390/biomedicines9121817