Molecule Information

General Information of the Molecule (ID: Mol01949)

Name	C-C motif chemokine receptor 5 (CCR5) ,Mus musculus
Synonyms	Ccr5; Cmkbr5 Click to Show/Hide
Molecule Type	Protein
Gene Name	CCR5
Gene ID	12774
Location	chr9:123,921,580-123,947,736[+]
Sequence	MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISC KKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFF IILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTC SPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIF AIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYA FVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL Click to Show/Hide
Function	Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Click to Show/Hide
Uniprot ID	CCR5_MOUSE
Ensembl ID	ENSMUSG00000079227
HGNC ID	HGNC:1606
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: 9989 Family: Muridae Genus: Mus Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Maraviroc

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Glioblastoma [ICD-11: 2A00.02]			[1]
Sensitive Disease	Glioblastoma [ICD-11: 2A00.02]		Disease Info
Sensitive Drug	Maraviroc		Drug Info
Molecule Alteration	Function	Inhibition
Experimental Note	Discovered Using In-vivo Testing Model
Cell Pathway Regulation	CCL5-CCR5 signaling pathway	Inhibition	has05163
In Vivo Model	Intracranial GBM patient-derived xenograft model		Mus musculus
Experiment for Molecule Alteration	Neutral comet assay; ELISA assay; Immunofluorescence staining analysis; Immunohistochemistry staining analysi; Immunoblot assay
Experiment for Drug Resistance	CCK-8 assay
Mechanism Description	The authors uncovered that pericytes potentiate DNA damage repair (DDR) in GBM cells residing in the perivascular niche, which induces temozolomide (TMZ) chemoresistance. Disrupting CCL5-CCR5 paracrine signaling through the brain-penetrable CCR5 antagonist maraviroc (MVC) potently inhibits pericyte-promoted DDR and effectively improves the chemotherapeutic efficacy of TMZ.

References

Ref 1	Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling .Cell Res. 2021 Oct;31(10):1072-1087. doi: 10.1038/s41422-021-00528-3. Epub 2021 Jul 8. 10.1038/s41422-021-00528-3