Molecule Information

General Information of the Molecule (ID: Mol01929)

Name	Transmembrane protein (TMEFF1) ,Homo sapiens
Synonyms	TMEFF1; C9orf2 Click to Show/Hide
Molecule Type	Protein
Gene Name	TMEFF1
Gene ID	8577
Location	chr9:100,473,149-100,577,636[+]
Sequence	MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGK SINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQN ECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECD EDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCR CESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNR GRRQKQNLGHFTSDTSSRMV Click to Show/Hide
Function	May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. Click to Show/Hide
Uniprot ID	TEFF1_HUMAN
Ensembl ID	ENSG00000241697
HGNC ID	HGNC:11866
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Butorphanol

Click to Show/Hide

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Ovarian cancer				[1]
Sensitive Disease	Ovarian cancer [ICD-11: 2C73.0]			Disease Info
Sensitive Drug	Butorphanol			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
In Vitro Model	LN308 cells	Brain	Homo sapiens (Human)	CVCL_0394
	Primary pulmonary lymphoepithelioma-like carcinoma tissue			.
	HCK1T cells	Ovary	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	CCK8 assay; Colony Formation assay; Transwell assay; Flow Cytometry
Mechanism Description	An important issue with compounds for treating ovarian cancer is the development of drug resistance and side effects. Butorphanol is a synthetic opioid. Opioids have been shown to promote or prevent tumor growth and metastasis. Butorphanol Inhibits the Malignant Biological Behaviors of Ovarian Cancer Cells via Down-Regulating the Expression of TMEFF1.

References

Ref 1	Butorphanol Inhibits the Malignant Biological Behaviors of Ovarian Cancer Cells via Down-Regulating the Expression of TMEFF1 .Onco Targets Ther. 2020 Oct 28;13:10973-10981. doi: 10.2147/OTT.S244928. eCollection 2020. 10.2147/OTT.S244928