Molecule Information

General Information of the Molecule (ID: Mol01816)

Name	hsa-miR-106b~25 ,Homo sapiens
Molecule Type	Mature miRNA
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Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

4 drug(s) in total

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Colchicine

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Breast cancer				[1]
Resistant Disease	Breast cancer [ICD-11: 2C60.3]			Disease Info
Resistant Drug	Colchicine			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	miR106b~25 cluster/EP300/E-cadherin signaling pathway		Regulation	hsa05206
In Vitro Model	MTMECs cells	Breast	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-106b~25 cluster controls transporter-independent MDR by apoptosis evasion via downregulation of EP300.

Cyclosporin A

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Breast cancer				[1]
Resistant Disease	Breast cancer [ICD-11: 2C60.3]			Disease Info
Resistant Drug	Cyclosporin A			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	miR106b~25 cluster/EP300/E-cadherin signaling pathway		Regulation	hsa05206
In Vitro Model	MTMECs cells	Breast	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-106b~25 cluster controls transporter-independent MDR by apoptosis evasion via downregulation of EP300.

Etoposide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Breast cancer				[1]
Resistant Disease	Breast cancer [ICD-11: 2C60.3]			Disease Info
Resistant Drug	Etoposide			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	miR106b~25 cluster/EP300/E-cadherin signaling pathway		Regulation	hsa05206
In Vitro Model	MTMECs cells	Breast	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-106b~25 cluster controls transporter-independent MDR by apoptosis evasion via downregulation of EP300.

Paclitaxel

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Breast cancer				[1]
Resistant Disease	Breast cancer [ICD-11: 2C60.3]			Disease Info
Resistant Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	miR106b~25 cluster/EP300/E-cadherin signaling pathway		Regulation	hsa05206
In Vitro Model	MTMECs cells	Breast	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-106b~25 cluster controls transporter-independent MDR by apoptosis evasion via downregulation of EP300.

References

Ref 1	MiR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300. Oncol Rep. 2016 Feb;35(2):1170-8. doi: 10.3892/or.2015.4412. Epub 2015 Nov 12.