Molecule Information

General Information of the Molecule (ID: Mol01768)

• Name: hsa-miR-4443 ,Homo sapiens
• Synonyms: microRNA 4443
• Molecule Type: Mature miRNA
• Sequence: UUGGAGGCGUGGGUUUU
• Ensembl ID: ENSG00000265483
• HGNC ID: HGNC:41830
• Mature Accession: MIMAT0018961

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Epirubicin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Non-small cell lung cancer [1]

• Resistant Disease: Non-small cell lung cancer [ICD-11: 2C25.Y]
• Resistant Drug: Epirubicin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell colony; Activation; hsa05200
• Cell Pathway Regulation: Cell viability; Activation; hsa05200
• Cell Pathway Regulation: JAKT2/STAT3 signaling pathway; Activation; hsa04030
• In Vitro Model: H1299 cells; Lung; Homo sapiens (Human); CVCL_0060
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: MTT assay; Flow cytometry assay
• Mechanism Description: Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by downregulating INPP4A and regulating the activation of JAk2/STAT3 pathway.

References

• Ref 1: Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway. Pharmazie. 2018 Jul 1;73(7):386-392. doi: 10.1691/ph.2018.8313.