Molecule Information

General Information of the Molecule (ID: Mol01748)

• Name: hsa-miR-663b ,Homo sapiens
• Synonyms: microRNA 663b
• Molecule Type: Mature miRNA
• Sequence: GGUGGCCCGGCCGUGCCUGAGG
• Ensembl ID: ENSG00000221288
• HGNC ID: HGNC:35270
• Mature Accession: MIMAT0005867

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tamoxifen

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Breast cancer [1]

• Resistant Disease: Breast cancer [ICD-11: 2C60.3]
• Resistant Drug: Tamoxifen
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell proliferation; Activation; hsa05200
• In Vitro Model: MCF-7 cells; Breast; Homo sapiens (Human); CVCL_0031
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: MTT assay; Flow cytometry assay
• Mechanism Description: microRNA 663b mediates TAM resistance in breast cancer by downrerulating TP73 expression.

References

• Ref 1: MicroRNA 663b mediates TAM resistance in breast cancer by modulating TP73 expression. Mol Med Rep. 2018 Jul;18(1):1120-1126. doi: 10.3892/mmr.2018.9064. Epub 2018 May 23.