Molecule Information

General Information of the Molecule (ID: Mol01730)

• Name: hsa-miR-625-3p ,Homo sapiens
• Synonyms: microRNA 625
• Molecule Type: Mature miRNA
• Sequence: GACUAUAGAACUUUCCCCCUCA
• Ensembl ID: ENSG00000207781
• HGNC ID: HGNC:32881
• Mature Accession: MIMAT0004808

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Oxaliplatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Colorectal adenocarcinoma [1]

• Resistant Disease: Colorectal adenocarcinoma [ICD-11: 2B91.2]
• Resistant Drug: Oxaliplatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell proliferation; Activation; hsa05200
• Cell Pathway Regulation: p38/MAPK signaling pathway; Inhibition; hsa04010
• In Vitro Model: HEK293 Flp pFRT/eGFP cells; Kidney; Homo sapiens (Human); CVCL_U427
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: Inactivation of MAP2k6-p38 signalling as one likely mechanism of oxaliplatin resistance, and miR-625-3p induces oxaliplatin resistance by abrogating MAP2k6-p38-regulated apoptosis and cell cycle control networks.

References

• Ref 1: miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells. Nat Commun. 2016 Aug 16;7:12436. doi: 10.1038/ncomms12436.