Molecule Information

General Information of the Molecule (ID: Mol01311)

• Name: HIF1A antisense RNA 3 (HIF1A-AS3) ,Homo sapiens
• Synonyms: HIF1A-AS3
• Molecule Type: LncRNA
• Gene Name: ROR, lincRNA-RoR, lincRNA-ST8SIA3
• Gene ID: 105370526
• Location: chr14:61707564-61751099[-]
• Ensembl ID: ENSG00000258667
• HGNC ID: HGNC:54284

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cisplatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Bladder cancer [ICD-11: 2C94.0] [1]

• Resistant Disease: Bladder cancer [ICD-11: 2C94.0]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation

Differential expression of the molecule in resistant disease

• Classification of Disease: Bladder cancer [ICD-11: 2C94]
• The Specified Disease: Bladder urothelial carcinoma
• The Studied Tissue: Bladder
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 4.71E-01; Fold-change: 3.16E-01; Z-score: 7.34E-01
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• In Vitro Model: 5637 cells; Bladder; Homo sapiens (Human); CVCL_0126
• In Vitro Model: T24 cells; Bladder; Homo sapiens (Human); CVCL_0554
• In Vitro Model: SW780 cells; Bladder; Homo sapiens (Human); CVCL_1728
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: MTT assay; Flow cytometry assay
• Mechanism Description: Upregulated HIF1A-AS2 hampers the p53 family proteins dependent apoptotic pathway to promote Cis resistance in bladder cancer.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Bladder cancer [ICD-11: 2C94]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Bladder
• The Specified Disease: Bladder urothelial carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 6.28E-01; Fold-change: -6.62E-02

References

• Ref 1: The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer. J Cell Biochem. 2019 Jan;120(1):243-252. doi: 10.1002/jcb.27327. Epub 2018 Sep 14.