Molecule Information

General Information of the Molecule (ID: Mol01288)

Name	OIP5 antisense RNA 1 (OIP5-AS1) ,Homo sapiens
Synonyms	OIP5-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	OIP5-AS1
Gene ID	729082
Location	chr15:41283990-41309737[+]
Ensembl ID	ENSG00000247556
HGNC ID	HGNC:43563
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Osteosarcoma [ICD-11: 2B51.0]				[1]
Resistant Disease	Osteosarcoma [ICD-11: 2B51.0]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	PI3K/AKT/mTOR signaling pathway		Activation	hsa04151
In Vitro Model	MG63 cells	Bone marrow	Homo sapiens (Human)	CVCL_0426
	SAOS-2 cells	Bone marrow	Homo sapiens (Human)	CVCL_0548
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	OIP5-AS1 regulates cisplatin resistance by activating the PI3k/AkT/mTOR signaling pathway.

Paclitaxel

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Ovarian cancer [ICD-11: 2C73.0]				[2]
Resistant Disease	Ovarian cancer [ICD-11: 2C73.0]			Disease Info
Resistant Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	A2780 cells	Ovary	Homo sapiens (Human)	CVCL_0134
Experiment for Molecule Alteration	RT-PCR; LncRNA and mRNA sequencing
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	To further identify the potential mRNA targets of the MDR linked lncRNAs, the 9 potential MDR linked lncRNAs and mRNAs co-expression network was generated. Finally, 1428 mRNAs were considered to be coexpressed with the 9 potential MDR linked lncRNAs (pearson coefficiency >0.90 and q<0.05). In particular, we noticed that lncRNA CTD-2589M5.4 was co-expressed with 806 genes, including the MDR linked genes: ABCB1, ABCB4, ABCC3, and ABCG2 (pearson co-efficiency =0.986, 0.952, 0.961, and 0.999, respectively) and the mesothelin encoded protein MSLN which was considered to be the marker of ovarian cancer, colon cancer and so on.

References

Ref 1	Long noncoding RNA OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATBeta/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p. J Cell Biochem. 2019 Jun;120(6):9656-9666. doi: 10.1002/jcb.28244. Epub 2018 Dec 11.
Ref 2	Wnt/Beta-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal TumorMol Cancer Ther. 2017 Sep;16(9):1954-1966. doi: 10.1158/1535-7163.MCT-17-0139. Epub 2017 Jun 13.