Molecule Information

General Information of the Molecule (ID: Mol01276)

Name	HOXA11 antisense RNA (HOXA11-AS) ,Homo sapiens
Synonyms	HOXA11-AS Click to Show/Hide
Molecule Type	LncRNA
Gene Name	ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, RP11-145E5.4, p15AS
Gene ID	221883
Location	chr7:27184507-27189298[+]
Ensembl ID	ENSG00000240990
HGNC ID	HGNC:24957
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Disease Class: Lung adenocarcinoma				[1]
Resistant Disease	Lung adenocarcinoma [ICD-11: 2C25.0]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell colony		Activation	hsa05200
	Cell invasion		Activation	hsa05200
	Cell viability		Activation	hsa05200
In Vitro Model	A549 cells	Lung	Homo sapiens (Human)	CVCL_0023
	H157 cells	Lung	Homo sapiens (Human)	CVCL_2458
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay; Flow cytometry assay
Mechanism Description	LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via upregulating Stat3 by sequestering miR-454-3p.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Lung cancer [ICD-11: 2C25]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Lung
The Specified Disease	Lung adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.94E-08; Fold-change: -6.35E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual
The Studied Tissue	Lung
The Specified Disease	Lung squamous cell carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.22E-27; Fold-change: -9.91E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via modulating miR-454-3p/Stat3. Cancer Sci. 2018 Oct;109(10):3068-3079. doi: 10.1111/cas.13764. Epub 2018 Sep 2.