Molecule Information

General Information of the Molecule (ID: Mol01272)

Name	NCK1 divergent transcript (NCK1-DT) ,Homo sapiens
Synonyms	NCK1-DT Click to Show/Hide
Molecule Type	LncRNA
Gene Name	CTA-941F9.9, TCONS_00029353
Gene ID	101927597
Location	chr3:136835345-136862618[-]
Ensembl ID	ENSG00000239213
HGNC ID	HGNC:49645
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cervical cancer				[1]
Sensitive Disease	Cervical cancer [ICD-11: 2C77.0]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
In Vitro Model	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
Experiment for Molecule Alteration	RT-qPCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	Silencing of NCk1-AS1 and upregulation of miR-134-5p promote HeLa cell apoptosis and reduce cisplatin resistance in cervical cancer cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Cervical cancer [ICD-11: 2C77]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Cervix uteri
The Specified Disease	Cervical and endocervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.75E-14; Fold-change: -3.32E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Suppression of long noncoding RNA NCK1-AS1 increases chemosensitivity to cisplatin in cervical cancer. J Cell Physiol. 2019 Apr;234(4):4302-4313. doi: 10.1002/jcp.27198. Epub 2018 Sep 17.