Molecule Information

General Information of the Molecule (ID: Mol01267)

Name	Gastric cancer associated transcript 3 (GACAT3) ,Homo sapiens
Synonyms	GACAT3 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	EGO, NCRNA00190
Gene ID	104797537
Location	chr2:16013928-16087201[+]
Ensembl ID	ENSG00000236289
HGNC ID	HGNC:50847
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Clinical Trial Drug(s)

1 drug(s) in total

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Cucurbitacin B

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Gastric cancer				[1]
Resistant Disease	Gastric cancer [ICD-11: 2B72.1]			Disease Info
Resistant Drug	Cucurbitacin B			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
In Vitro Model	BGC-823 cells	Gastric	Homo sapiens (Human)	CVCL_3360
	SGC7901 cells	Gastric	Homo sapiens (Human)	CVCL_0520
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	GACAT3 alleviates the anticancer drug cucurbitacin B-induced apoptosis of gastric cancer cells via increasing STAT3 expression.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Gastric cancer [ICD-11: 2B72]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Stomach
The Specified Disease	Stomach adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.26E-01; Fold-change: -3.22E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells. Gene. 2018 Dec 15;678:164-171. doi: 10.1016/j.gene.2018.08.037. Epub 2018 Aug 8.