Molecule Information

General Information of the Molecule (ID: Mol01266)

• Name: Eosinophil granule ontogeny transcript (EGOT) ,Homo sapiens
• Synonyms: EGOT
• Molecule Type: LncRNA
• Gene Name: EGOT
• Gene ID: 100126791
• Location: chr3:4749192-4751590[-]
• Ensembl ID: ENSG00000235947
• HGNC ID: HGNC:37129

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Paclitaxel

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Breast cancer [1]

• Sensitive Disease: Breast cancer [ICD-11: 2C60.3]
• Sensitive Drug: Paclitaxel
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell autophagy; Activation; hsa04140
• In Vitro Model: UACC-812 cells; Breast; Homo sapiens (Human); CVCL_1781
• In Vivo Model: Athymic BALB/c nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: EGOT induces autophagy to enhance paclitaxel sensitivity through ITPR1.

References

• Ref 1: Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer. Mol Cancer. 2019 Apr 18;18(1):89. doi: 10.1186/s12943-019-1017-z.