Molecule Information

General Information of the Molecule (ID: Mol01253)

Name	TRPM2 antisense RNA (TRPM2-AS) ,Homo sapiens
Synonyms	TRPM2-AS Click to Show/Hide
Molecule Type	LncRNA
Gene Name	DXS1089, DXS399E, LINC00001, NCRNA00001, swd66
Gene ID	101928607
Location	chr21:44414588-44425272[-]
Ensembl ID	ENSG00000230061
HGNC ID	HGNC:50758
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Non-small cell lung cancer				[1]
Sensitive Disease	Non-small cell lung cancer [ICD-11: 2C25.Y]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	p53/p66shc signaling pathway		Activation	hsa04115
In Vitro Model	A549 cells	Lung	Homo sapiens (Human)	CVCL_0023
	A549/DDP cells	Lung	Homo sapiens (Human)	CVCL_0023
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometric analysis
Mechanism Description	Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Lung cancer [ICD-11: 2C25]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Lung
The Specified Disease	Lung adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.42E-37; Fold-change: -8.17E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Lung
The Specified Disease	Lung squamous cell carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.23E-102; Fold-change: -1.09E+00
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway. Eur Rev Med Pharmacol Sci. 2017 Jun;21(11):2626-2634.