Molecule Information

General Information of the Molecule (ID: Mol01250)

• Name: CCDC26 long non-coding RNA (CCDC26) ,Homo sapiens
• Synonyms: CCDC26
• Molecule Type: LncRNA
• Gene Name: CES1A3, CES4, CESR, PCE-3
• Gene ID: 137196
• Location: chr8:128634199-129683770[-]
• Ensembl ID: ENSG00000229140
• HGNC ID: HGNC:28416

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Imatinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Gastrointestinal stromal tumor [1]

• Resistant Disease: Gastrointestinal stromal tumor [ICD-11: 2B5B.0]
• Resistant Drug: Imatinib
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• In Vitro Model: GIST-T1 cells; Gastric; Homo sapiens (Human); CVCL_4976
• In Vitro Model: GIST882 cells; Gastric; Homo sapiens (Human); CVCL_7044
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: Down-regulation of LncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation.

Disease Class: Gastrointestinal stromal tumor [2]

• Resistant Disease: Gastrointestinal stromal tumor [ICD-11: 2B5B.0]
• Resistant Drug: Imatinib
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell viability; Activation; hsa05200
• In Vitro Model: GIST-T1 cells; Gastric; Homo sapiens (Human); CVCL_4976
• In Vitro Model: GIST882 cells; Gastric; Homo sapiens (Human); CVCL_7044
• Experiment for Molecule Alteration: qPCR
• Experiment for Drug Resistance: CCK8 assay; EdU assay; Flow cytometry assay
• Mechanism Description: CCDC26 knockdown enhanced imatinib resistance in GIST cells and c-kIT knockdown reversed the imatinib resistance mediated by CCDC26 inhibition.

References

• Ref 1: Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation. Braz J Med Biol Res. 2019;52(6):e8399. doi: 10.1590/1414-431x20198399. Epub 2019 Jun 3.
• Ref 2: CCDC26 knockdown enhances resistance of gastrointestinal stromal tumor cells to imatinib by interacting with c-KIT. Am J Transl Res. 2018 Jan 15;10(1):274-282. eCollection 2018.