Molecule Information

General Information of the Molecule (ID: Mol01244)

Name	Long non-protein coding RNA 161 (LINC00161) ,Homo sapiens
Synonyms	LINC00161 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	THOR
Gene ID	118421
Location	chr21:28539318-28540355[+]
Ensembl ID	ENSG00000226935
HGNC ID	HGNC:17138
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Ovarian cancer				[1]
Resistant Disease	Ovarian cancer [ICD-11: 2C73.0]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	MAPK signaling pathway		Activation	hsa04010
In Vitro Model	SkOV3 cells	Ovary	Homo sapiens (Human)	CVCL_0532
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay; Colony formation assays
Mechanism Description	Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPk1.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Osteosarcoma				[2]
Sensitive Disease	Osteosarcoma [ICD-11: 2B51.0]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	MG63 cells	Bone marrow	Homo sapiens (Human)	CVCL_0426
	U2OS cells	Bone	Homo sapiens (Human)	CVCL_0042
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Ckk-8 assay; Colony formation assay; Annexin V-FITC staining assay
Mechanism Description	Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR645-IFIT2 axis. LINC00161 acted as a miR645 sponge and inhibited its activity.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Ovarian cancer [ICD-11: 2C73]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Ovary
The Specified Disease	Ovarian serous cystadenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.40E-15; Fold-change: 3.28E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1. Mol Carcinog. 2019 Apr;58(4):577-587. doi: 10.1002/mc.22952. Epub 2019 Jan 22.
Ref 2	Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. Cancer Lett. 2016 Nov 28;382(2):137-146. doi: 10.1016/j.canlet.2016.08.024. Epub 2016 Sep 5.