Molecule Information

General Information of the Molecule (ID: Mol01241)

• Name: Surfactant associated 1, LncRNA (SFTA1P) ,Homo sapiens
• Synonyms: SFTA1P
• Molecule Type: LncRNA
• Gene Name: HOXD-AS1, MIR7704HG, Mdgt
• Gene ID: 207107
• Location: chr10:10784437-10795047[-]
• Ensembl ID: ENSG00000225383
• HGNC ID: HGNC:18383

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cisplatin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Lung squamous cell carcinoma [ICD-11: 2C25.3] [1]

• Sensitive Disease: Lung squamous cell carcinoma [ICD-11: 2C25.3]
• Sensitive Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell apoptosis; Activation; hsa04210
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: H1299 cells; Lung; Homo sapiens (Human); CVCL_0060
• In Vitro Model: Sk-MES-1 cells; Lung; Homo sapiens (Human); CVCL_0630
• In Vitro Model: 16HBE cells; Lung; Homo sapiens (Human); CVCL_0112
• In Vitro Model: A549-DDP cells; Lung; Homo sapiens (Human); CVCL_IP03
• In Vitro Model: NCl-H226 cells; Lung; Homo sapiens (Human); CVCL_1544
• Experiment for Molecule Alteration: RT-PCR
• Experiment for Drug Resistance: MTS Cell Proliferation Assay; EdU assay; Flow cytometry assay
• Mechanism Description: Long noncoding RNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity via regulating the hnRNP-U-GADD45A axis in lung squamous cell carcinoma. SFTA1P could up-regulate hnRNP-U expression. hnRNP-U enhanced cisplatin-induced apoptosis through up-regulation of GADD45A.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Lung cancer [ICD-11: 2C25]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Lung
• The Specified Disease: Lung adenocarcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 1.96E-74; Fold-change: 1.88E-01
• The Studied Tissue: Lung
• The Specified Disease: Lung squamous cell carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 1.90E-290; Fold-change: 5.22E-01

References

• Ref 1: Long noncoding RNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity via regulating the hnRNP-U-GADD45A axis in lung squamous cell carcinoma. Oncotarget. 2017 Oct 27;8(57):97476-97489. doi: 10.18632/oncotarget.22138. eCollection 2017 Nov 14.