Molecule Information

General Information of the Molecule (ID: Mol01218)

• Name: MIR4435-2 host gene (MIR4435-2HG) ,Homo sapiens
• Synonyms: MIR4435-2HG
• Molecule Type: LncRNA
• Gene Name: LOC554202, LncHIFCAR, hsa-lnc-31
• Gene ID: 541471
• Location: chr2:111006015-111523376[-]
• Ensembl ID: ENSG00000172965
• HGNC ID: HGNC:35163

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cisplatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Non-small cell lung cancer [ICD-11: 2C25.Y] [1]

• Resistant Disease: Non-small cell lung cancer [ICD-11: 2C25.Y]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation

Differential expression of the molecule in resistant disease

• Classification of Disease: Lung cancer [ICD-11: 2C25]
• The Specified Disease: Lung adenocarcinoma
• The Studied Tissue: Lung
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 4.02E-10; Fold-change: 4.79E-01; Z-score: 6.32E+00
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell proliferation; Activation; hsa05200
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: MTT assay; Flow cytometric analysis
• Mechanism Description: LncRNA Ak001796 increased the resistance of NSCLC cells to cisplatin through regulating cell apoptosis and cell proliferation.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Lung cancer [ICD-11: 2C25]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Lung
• The Specified Disease: Lung adenocarcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 1.76E-14; Fold-change: -3.76E-02
• The Studied Tissue: Lung
• The Specified Disease: Lung squamous cell carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 5.83E-27; Fold-change: -5.37E-02

References

• Ref 1: Long non coding RNA AK001796 contributes to cisplatin resistance of non small cell lung cancer. Mol Med Rep. 2017 Oct;16(4):4107-4112. doi: 10.3892/mmr.2017.7081. Epub 2017 Jul 24.