Molecule Information

General Information of the Molecule (ID: Mol01218)

Name	MIR4435-2 host gene (MIR4435-2HG) ,Homo sapiens
Synonyms	MIR4435-2HG Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LOC554202, LncHIFCAR, hsa-lnc-31
Gene ID	541471
Location	chr2:111006015-111523376[-]
Ensembl ID	ENSG00000172965
HGNC ID	HGNC:35163
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Non-small cell lung cancer				[1]
Resistant Disease	Non-small cell lung cancer [ICD-11: 2C25.Y]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
In Vitro Model	A549 cells	Lung	Homo sapiens (Human)	CVCL_0023
Experiment for Molecule Alteration	RT-qPCR
Experiment for Drug Resistance	MTT assay; Flow cytometric analysis
Mechanism Description	LncRNA Ak001796 increased the resistance of NSCLC cells to cisplatin through regulating cell apoptosis and cell proliferation.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Lung cancer [ICD-11: 2C25]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Lung
The Specified Disease	Lung adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.76E-14; Fold-change: -3.76E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Lung
The Specified Disease	Lung squamous cell carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.83E-27; Fold-change: -5.37E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Long non coding RNA AK001796 contributes to cisplatin resistance of non small cell lung cancer. Mol Med Rep. 2017 Oct;16(4):4107-4112. doi: 10.3892/mmr.2017.7081. Epub 2017 Jul 24.