Molecule Information

General Information of the Molecule (ID: Mol01187)

• Name: Defensin resistance ABC transporter DerAB (DERAB) ,Lactobacillus casei
• Molecule Type: Protein
• Gene Name: DerAB

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lacticaseibacillus
Species: Lacticaseibacillus casei

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Corticostatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Lactobacillus casei infection [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Corticostatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Escherichia coli DH10beta; 316385
• In Vitro Model: Lactococcus lactis MG1363; 1358
• Experiment for Molecule Alteration: Real-time PCR
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. The transporter specifically conferred resistance against insect-derived cysteine-stabilized alphabeta defensins, and it was therefore renamed DerAB for defensin resistance ABC trans.

References

• Ref 1: ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins. Appl Environ Microbiol. 2020 Jul 2;86(14):e00818-20. doi: 10.1128/AEM.00818-20. Print 2020 Jul 2.