Molecule Information

General Information of the Molecule (ID: Mol01136)

• Name: Virginiamycin B lyase (VGBC) ,Paenibacillus sp.
• Synonyms: Streptogramin B lyase; vgb; AK95_08365
• Molecule Type: Protein
• Gene Name: vgbC
• Sequence:
  MQIAAQEYKTANRESGPYGITARQDRTIWFTEQKGNRIGRLTKDGDMRTFEVPTPDAGVM
  SILSAHTGDLWFTEYKANKIGRMTMEGTFAEFELPEANSSPYGLAEGPDGAIWFTELSGN
  RIGRITPAGIITEYDLPCEGSYPSYITAGPDGALWFTENQNNCIGRITVDGEITEYRIPT
  EQSGPVGITTGADGALWFVQINGNQIGRITTAGEITEFKLPSGNARPHAITAGVSGDLWF
  TEWGANQIGRITCTGDITEYPIPTPSAEPHGITVDSGGEVWFAEECDQIGRFTIQY
• Function: Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
• Uniprot ID: A0A1I9ZKK6_9BACL

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Paenibacillaceae
Genus: Paenibacillus
Species: Paenibacillus sp.

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Linopristin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Linopristin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Paenibacillus sp. LC231; 1120679
• Experiment for Molecule Alteration: Whole genome sequence assay
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: Vgb is a streptogramin B lyase and VgbC inactivates linopristin by Beta-elimination.

References

• Ref 1: A diverse intrinsic antibiotic resistome from a cave bacterium. Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.