Molecule Information

General Information of the Molecule (ID: Mol01104)

• Name: Tetracycline efflux protein TetA (TETA) ,Corynebacterium glutamicum
• Synonyms: tetA(33); TetA protein
• Molecule Type: Protein
• Gene Name: tetA(33)
• Sequence:
  MSSLTSARGSLATVLITASLDAAGMGLVMPILPALLHEAGVTADAVPLNVGVLIALYAVM
  QFIFAPVLGTLSDRFGRRRVLLVSLAGATVDYLVLATTSALSVFYIARAVAGITGATNAV
  TATVIADITPPHQRAKRFGLLSACYGGGMIAGPAMGGLFGAISPHLPFLLAALLSASNLA
  LTFILLRETRPDSPARSASLAQHRGRPGLSAVPGITFLLIAFGLVQFIGQAPGATWVLFT
  EHRLDWSPVEVGISLSVFGIVQVLVQALLTGRIVEWIGEAKTVIIGCITDALGLVGLAIV
  TDAFSMAPILAALGIGGIGLPALQTLLSQRVDEQHQGRLQGVLASINSVTSIFGPVAFTT
  IFALTYINADGFLWLCAAALYVPCVILIMRGTAASPKFGSWASGDSM
• Uniprot ID: Q8VVJ1_CORGT

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium glutamicum

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tetracycline

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Corynebacterium glutamicum infection [1]

• Resistant Disease: Corynebacterium glutamicum infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Tetracycline
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Corynebacterium glutamicum ATCC 13032; 196627
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Macrodilution broth method assay
• Mechanism Description: Tet33 causes tetracycline resistance by regulating tetracycline efflux.

References

• Ref 1: The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. Plasmid. 2002 Sep;48(2):117-29. doi: 10.1016/s0147-619x(02)00120-8.