Molecule Information

General Information of the Molecule (ID: Mol01089)

• Name: Sterol 14-alpha demethylase cyp51A (CYP51A) ,Aspergillus terreus
• Synonyms: ATEIFO6365_0007029700; ATETN484_0009029700
• Molecule Type: Protein
• Gene Name: ATEIFO6365_0007029700
• Sequence:
  MIMSLLTITSYSAVGILALIAWNVIRQLLFQNKSEPPVVFHWIPFLGSTISYGIDPYAFF
  ASCRQKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVY
  DCPNAKLMEQKKFIKYGLTQAALESHVQLIEREVLDYLRTSPNFHGASGVVDISAAMAEL
  TIFTAGRALQGEEVRRKLTAEFADLYHDLDKGFTPINFMLPWAPLPHNRKRDAAHARMRA
  IYMDIIRERRAHKNPDQGEAGSDSDMIWNLMRCTYKDGRPVPDKEIAHMMITLLMAGQHS
  SSSISAWIFLRLASEPRVLEELYQEQVASLGKPDADGAFPPLQFRDLDRLPLHQNVVKET
  LRLHSSIHSIMRKVKNPLPVPGTPYVVPTSHVLLASPGVTATSDEYFPNASRWDPHRWEN
  HAEPDDDDGEMVDYGYGRVSKGTASPYLPFGGGRHRCIGEKFAYINLGVIVATVVRHLKL
  FNVDGRKGVPPTDYSSLFSGPLKPAIIGWERRFPTA
• Uniprot ID: A0A5M3Z4K7_ASPTE

Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species: Aspergillus terreus

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Itraconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Chronic noninvasive aspergillosis [1]

• Resistant Disease: Chronic noninvasive aspergillosis [ICD-11: 1F20.4]
• Resistant Drug: Itraconazole
• Molecule Alteration: Missense mutation; p.M217I
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Aspergillus terreus strain; 33178
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: In vivo emergence of Aspergillus terreus with reduced azole susceptibility which is related to Cyp51a M217I alteration.

References

• Ref 1: In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration. J Infect Dis. 2012 Sep 15;206(6):981-5. doi: 10.1093/infdis/jis442. Epub 2012 Jul 10.