Molecule Information

General Information of the Molecule (ID: Mol00988)

• Name: Lincosamide nucleotidyltransferase (LNUG) ,Enterococcus faecalis
• Synonyms: lnu(G); lnuG; EY666_09475; G)
• Molecule Type: Protein
• Gene Name: lnu(G)
• Sequence:
  MLKQKELMARVKELVQSDERISACMMYGSFTKGEGDQYSDIEYYVFLKDDTISTFDSAKW
  LNEVASYTLLYQNEYGTEVVIFENLIRGEFHFLSENEMNIIPSFKESGYIPDTKAMFIYD
  ETGQLELYLSELEGPGPNRLTEENVNFLLNNFSNLWLMGINVLKRGENARSLELLSQLQK
  NILQLIRIAEENADNWFNMTKNLEKEISPENYEKFKKTTARLNELELYEAYKNSLLLVME
  LRNLVEKQYQLTISDDFLGKLFNYMNE
• Uniprot ID: A0A1L7HA90_ENTFL

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Lincomycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Enterococcus faecalis infection [1]

• Resistant Disease: Enterococcus faecalis infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Lincomycin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Enterococcus faecalis; 1351
• Experiment for Molecule Alteration: PCR; DNA sequence assay
• Mechanism Description: A novel resistance gene, designated lnu(G), which encodes a putative lincosamide nucleotidyltransferase, was found in E. faecalis E531.

References

• Ref 1: Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J Antimicrob Chemother. 2017 Apr 1;72(4):993-997. doi: 10.1093/jac/dkw549.