Molecule Information

General Information of the Molecule (ID: Mol00977)

• Name: Hydrolase (HYDE) ,Salmonella enterica serovar Typhimurium
• Synonyms: ELS01_26210; G0M02_24435; G0M02_24760
• Molecule Type: Protein
• Gene Name: ELS01_26210
• Sequence:
  MPVLFRVKVIPLVLLLAMIFAFLLNWPILLHFYEILSHLEHVKIGFVISIPFVLVAALNV
  VFMPFSVRFLLKPFFALLFITGSLVSYSTLKYKVMFDQTMIQNIIETNPQEAHSYLNGSI
  IIWFVFTGILPAILLFSIKIQYPEKWYKGIAYRLLSVLASLSLIAGVAALYYQDYASVGR
  NNSTLNKEIIPANYAYSTFQYVKDTYFTTKVPFQTLGNDAKRVVAHEKPTLMFLVIGETA
  RSQNFSMNGYSRDTNAFTSKSGGVISFKNMHSCGTATAISVPCMFSNMNRTEYDSKKASN
  SENFLDIVQKTGVSLLWKENDGGCKGVCSRIPTVEIKPSDNPKLCDGKTCHDEVMLENLD
  DEIAKMPGDKLVAFHIIGSHGPTYYLRYPAEHRHFMPECARSDIENCTQEQLVNTYDNTL
  RYTDYVLAEMIEKLKNYSDQYNTVLLYVSDHGESLGESGLYLHGTPYKLAPDQQTHIPMQ
  VWMSPGFIAGKHINMSCLENNAAKKSYSHDNLFSSILGLWDVSTSVYNPDRDLFRECRG
• Uniprot ID: A0A1I9W690_SALTM

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica subsp. enterica serovar Typhimurium

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Colistin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Salmonella enterica infection [1]

• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Resistant Drug: Colistin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli NEB5alpha; 562
• Experiment for Molecule Alteration: In silico EMBOSS Transeq assay
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: Mcr-1 is a phosphoethanolamine transferase that modifies cell membrane lipid A head groups with a phosphoethanolamine residue, reducing affinity to colistin.

References

• Ref 1: Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate. mBio. 2019 May 7;10(3):e00853-19. doi: 10.1128/mBio.00853-19.