Molecule Information

General Information of the Molecule (ID: Mol00967)

• Name: Fluoroquinolone efflux MFS transporter QepA1 (QEPA1) ,Escherichia coli
• Synonyms: pef; QepA; qepA; qepA1; BVL39_07900; EHH55_26410; IPF_141; pHN3A11_013; Plasmid efflux fluoroquinolone; QepA protein; Quinolone efflux pump
• Molecule Type: Protein
• Gene Name: pef
• Sequence:
  MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLW
  ILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAAFFAFASVLAALADTAALLIAARALLG
  LAGATIAPSTMALVRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFW
  LNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASM
  AALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYL
  QLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQ
  GLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGS
  VGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDAL
  QATAWAGAVLVLVAAGLVARLLRKRPALASG
• Uniprot ID: A5H8A5_ECOLX

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Fluoroquinolones

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Fluoroquinolones
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli C316; 562
• Experiment for Molecule Alteration: DNA sequencing and alignment assay
• Experiment for Drug Resistance: Agar dilution method assay
• Mechanism Description: QepA is a new quinolone efflux pump protein responsible for fluoroquinolone resistance.

References

• Ref 1: New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2007 Sep;51(9):3354-60. doi: 10.1128/AAC.00339-07. Epub 2007 Jun 4.