Molecule Information

General Information of the Molecule (ID: Mol00967)

Name	Fluoroquinolone efflux MFS transporter QepA1 (QEPA1) ,Escherichia coli
Synonyms	pef; QepA; qepA; qepA1; BVL39_07900; EHH55_26410; IPF_141; pHN3A11_013; Plasmid efflux fluoroquinolone; QepA protein; Quinolone efflux pump Click to Show/Hide
Molecule Type	Protein
Gene Name	pef
Sequence	MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLW ILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAAFFAFASVLAALADTAALLIAARALLG LAGATIAPSTMALVRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFW LNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASM AALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYL QLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQ GLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGS VGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDAL QATAWAGAVLVLVAAGLVARLLRKRPALASG Click to Show/Hide
Uniprot ID	A5H8A5_ECOLX
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Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluoroquinolones

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Bacterial infection [ICD-11: 1A00-1C4Z]			[1]
Resistant Disease	Bacterial infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Fluoroquinolones		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli C316		562
Experiment for Molecule Alteration	DNA sequencing and alignment assay
Experiment for Drug Resistance	Agar dilution method assay
Mechanism Description	QepA is a new quinolone efflux pump protein responsible for fluoroquinolone resistance.

References

Ref 1	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2007 Sep;51(9):3354-60. doi: 10.1128/AAC.00339-07. Epub 2007 Jun 4.