Molecule Information

General Information of the Molecule (ID: Mol00907)
Name
Dipeptide and tripeptide permease A (DTPA) ,Escherichia coli
Synonyms
tppB; ydgR; b1634; JW1626
    Click to Show/Hide
Molecule Type
Protein
Gene Name
dtpA
Gene ID
58463902
Sequence
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMA
AIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWS
VAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH
NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN
FFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMC
SGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
GSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP
KLHRMTQDDAADKAAKAAVA
    Click to Show/Hide
3D-structure
PDB ID
6GS4
Classification
Membrane protein
Method
X-ray diffraction
Resolution
2.65  Å
Function
Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.
    Click to Show/Hide
Uniprot ID
DTPA_ECOLI
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Type(s) of Resistant Mechanism of This Molecule
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Click to Show/Hide the Full List of Drugs
Chloramphenicol
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Disease Class: Escherichia coli infection [ICD-11: 1A03.0] [1]
Sensitive Disease Escherichia coli infection [ICD-11: 1A03.0]
 Disease Info 
Sensitive Drug Chloramphenicol
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model Escherichia coli BL21(DE3)pLysS cell 866768
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 Determination of MICs assay
Mechanism Description POT YdgR facilitates Cam uptake in E. coli.
References
Ref 1 The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. J Biol Chem. 2018 Jan 19;293(3):1007-1017. doi: 10.1074/jbc.M117.805960. Epub 2017 Nov 17.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Yu.