Molecule Information

General Information of the Molecule (ID: Mol00870)

Name	Chloramphenicol acetyltransferase (CAT) ,Bacillus pumilus
Synonyms	CAT; Cat-86 Click to Show/Hide
Molecule Type	Protein
Gene Name	cat86
Sequence	MFKQIDENYLRKEHFHHYMTLTRCSYSLVINLDITKLHAILKEKKLKVYPVQIYLLARAV QKIPEFRMDQVNDELGYWEILHPSYTILNKETKTFSSIWTPFDENFAQFYKSCVADIETF SKSSNLFPKPHMPENMFNISSLPWIDFTSFNLNVSTDEAYLLPIFTIGKFKVEEGKIILP VAIQVHHAVCDGYHAGQYVEYLRWLIEHCDEWLNDSLHIT Click to Show/Hide
Function	This enzyme is an effector of chloramphenicol resistance in bacteria. Click to Show/Hide
Uniprot ID	CAT_BACPU
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus pumilus

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Bacillus pumilus infection [ICD-11: 1C4Y.3]			[1]
Resistant Disease	Bacillus pumilus infection [ICD-11: 1C4Y.3]		Disease Info
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Bacillus pumilus strain NCIB8600		1408
	Bacillus subtilis strain BR151		1423
Experiment for Molecule Alteration	Restriction enzyme assay
Mechanism Description	Genes (cat) specifying the enzyme CAT occur in a wide range of unrelated bacteria, where they confer resistance to the antibiotic Cm. Gene cat-86 of Bacillus pumilus, specifying chloramphenicol-inducible chloramphenicol acetyltransferase, was previously cloned in Bacillus subtilis on plasmid pUB110.

References

Ref 1	Nucleotide sequence of a Bacillus pumilus gene specifying chloramphenicol acetyltransferase. Gene. 1983 Oct;24(2-3):163-9. doi: 10.1016/0378-1119(83)90076-8.