Molecule Information

General Information of the Molecule (ID: Mol00862)

• Name: Chloramphenicol acetyltransferase (CAT) ,Escherichia coli
• Molecule Type: Protein
• Gene Name: catIII
• Sequence:
  MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDDSAYKFYPVMIYLIAQ
  AVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPYSSDIDQFMVNYLSVME
  RYKSDTKLFPQGVTPENHLNISALPWVNFDSFNLNVANFTDYFAPIITMAKYQQEGDRLL
  LPLSVQVHHAVCDGFHVARFISRLQELCNSKLK
• Function: This enzyme is an effector of chloramphenicol resistance in bacteria.
• Uniprot ID: Q7B0A8_9BACT

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Chloramphenicol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Escherichia coli infection [ICD-11: 1A03.0] [1]

• Resistant Disease: Escherichia coli infection [ICD-11: 1A03.0]
• Resistant Drug: Chloramphenicol
• Molecule Alteration: Expression; Acquired
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Escherichia coli strain k12; 83333
• In Vitro Model: Escherichia coli strain JM111; 83333
• Experiment for Molecule Alteration: DNA sequencing assay
• Mechanism Description: Enzymic acetylation catalysed by chloramphenicol acetyltransferase is the commonest mechanism of bacterial resistance to the antibiotic chloramphenicol, an inhibitor of prokaryotic peptidyl-transferase activity.

References

• Ref 1: Nucleotide sequence analysis and overexpression of the gene encoding a type III chloramphenicol acetyltransferase. Biochem J. 1988 May 15;252(1):173-9. doi: 10.1042/bj2520173.