Molecule Information

General Information of the Molecule (ID: Mol00859)

• Name: CCAAT-binding factor complex subunit (HAPE) ,Aspergillus fumigatus
• Synonyms: hapE; CCAAT-binding transcription factor complex subunit
• Molecule Type: Protein
• Gene Name: hapE
• Sequence:
  MEQSSQSTAQQQGRQQPVYDTRNGGHYGASAALSAQGYAPVAELYTGTWANVNQGLQGTA
  RDILTTYWQHIINHLESDNHDYKIHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIF
  ITELTMRAWIHAEDNKRRTLQRSDIAAALSKSDMFDFLIDIVPREEATSHAKRSSQTTAG
  AAGSSAATGAQLPPSQHGVQHPPHHMGPPDYGSLGQHGMGQDQEYRQPTMYGGAVQSDPT
  AAYGQPQSQIFEGMYNPYPHLPPQQVCQNSS
• Uniprot ID: A0A1Y0LW31_ASPFM

Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species: Aspergillus fumigatus

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Itraconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Invasive aspergillosis [1]

• Resistant Disease: Invasive aspergillosis [ICD-11: 1F20.6]
• Resistant Drug: Itraconazole
• Molecule Alteration: Missense mutation; p.P88L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Aspergillus fumigatus strain; 746128
• Experiment for Molecule Alteration: Sanger sequencing assay
• Experiment for Drug Resistance: Growth kinetic assay
• Mechanism Description: Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing.

References

• Ref 1: Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing. PLoS One. 2012;7(11):e50034. doi: 10.1371/journal.pone.0050034. Epub 2012 Nov 30.