Molecule Information

General Information of the Molecule (ID: Mol00841)

• Name: Beta-lactamase (BLA) ,Mycolicibacterium fortuitum
• Synonyms: Penicillinase
• Molecule Type: Protein
• Gene Name: blaF
• Sequence:
  MTGLSRRNVLIGSLVAAAAVGAGVGGAAPAFAAPIDDQLAELERRDNVLIGLYAANLQSG
  RRITHRLDEMFAMCSTFKGYAAARVLQMAEHGEISLDNRVFVDADALVPNSPVTEARAGA
  EMTLAELCQAALQRSDNTAANLLLKTIGGPAAVTAFARSVGDERTRLDRWEVELNSAIPG
  DPRDTSTAAALAVGYRAILAGDALSPPQRGLLEDWMRANQTSSMRAGLPEGWTTADKTGS
  GDYGSTNDAGIAFGPDGQRLLLVMMTRSQAHDPKAENLRPLIGELTALVLPSLL
• Uniprot ID: BLAF_MYCFO

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycolicibacterium
Species: Mycolicibacterium fortuitum

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Amoxicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Mycobacterium fortuitum infection [1]

• Resistant Disease: Mycobacterium fortuitum infection [ICD-11: 1B2Z.2]
• Resistant Drug: Amoxicillin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli strain HB101; 634468
• In Vitro Model: Escherichia coli strain MC1061; 1211845
• In Vitro Model: Escherichia coli strain XL1-Blu9; 562
• In Vitro Model: Mycolicibacterium fortuitum strain D316; 1766
• In Vitro Model: Mycolicibacterium fortuitum strain FC1; 1766
• In Vitro Model: Mycolicibacterium smegmatis strain mc^155; 246196
• Experiment for Molecule Alteration: SDS-polyacrylamide gel assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: The gene encoding a class A (t-lactamase was cloned from a natural Isolate of Mycobacterium fortuitum {blaF) and from a high-level amoxicillJn-resistant mutant that produces large amounts of p-lactamase (blaF*).

References

• Ref 1: Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer. Mol Microbiol. 1994 May;12(3):491-504. doi: 10.1111/j.1365-2958.1994.tb01037.x.