Molecule Information

General Information of the Molecule (ID: Mol00815)

Name	Bcr/CflA family efflux transporter (BCML) ,Pseudomonas aeruginosa
Synonyms	cmlA1; cmlA6; IPC1317_27175 Click to Show/Hide
Molecule Type	Protein
Gene Name	CmlA6
Sequence	MRSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLV MIGAGQLLFGPLSDRLGRRPVLLGGGLAYVVASMGLALTSSAEVFLGLRILQACGASACL VSTFATVRDIYAGREESNVIYGILGSMLAIVPAVGPLLGALVDMWLGWRAIFAFLGLGMI AASAAAWRFWPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLM MGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITE IWALQSVLGFIAPMWLVGIGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGT LIISLLPRNTAWPVVVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAESTSNPNR Click to Show/Hide
Uniprot ID	Q933G9_PSEAI
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Pseudomonadaceae Genus: Pseudomonas Species: Pseudomonas aeruginosa

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Pseudomonas aeruginosa infection [ICD-11: 1A00-1C4Z]			[1]
Resistant Disease	Pseudomonas aeruginosa infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli DH10B		316385
	Pseudomonas aeruginosa PU21		287
	Escherichia coli strain k-12 C600		83333
	Pseudomonas aeruginosa 104116		287
	Pseudomonas aeruginosa SOF-1		287
Experiment for Molecule Alteration	Southern technique assay
Experiment for Drug Resistance	Agar dilution technique assay
Mechanism Description	An additional ORF located downstream corresponded to a cmlA-like gene that encodes CMLA6 for chloramphenicol resistance and that shared 99% amino acid identity with CMLA1, with only three amino acid changes.

References

Ref 1	Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2001 Jun;45(6):1615-20. doi: 10.1128/AAC.45.6.1615-1620.2001.