Molecule Information
General Information of the Molecule (ID: Mol00770)
| Name |
Aminocyclitol acetyltransferase ApmA (APMA)
,Staphylococcus aureus
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| Synonyms |
apmA; Aminocyclitol acetyltransferase ApmA
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| Molecule Type |
Protein
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| Gene Name |
apmA
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| Sequence |
MKTRLEQVLERYLNGREVAVWGVPTRRLLRALKPFKFHTADRVDPQYHYVVAVTDDDLTD
FLSDEQSKSFQYANDYLTFDDEGGELPFERMCFNVPVGRQTYFGDGVVGACENGYIKSIG QFTSINGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMTIG SDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENVPPFAVVVGVPARIKRYRFSKEMIET LLRVKWWDWSIEEINENVDALISPELFMKKYGSL Click to Show/Hide
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| 3D-structure |
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| Uniprot ID | |||||
| Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule
DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Clinical Trial Drug(s)
1 drug(s) in total
Apramycin
| Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
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Drug Inactivation by Structure Modification (DISM)
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| Disease Class: Bacterial infection [ICD-11: 1A00-1C4Z] | [1] | |||
| Resistant Disease | Bacterial infection [ICD-11: 1A00-1C4Z] | |||
| Resistant Drug | Apramycin | |||
| Molecule Alteration | Expression | Up-regulation |
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| Experimental Note | Discovered Using In-vivo Testing Model | |||
| In Vitro Model | Staphylococcus aureus RN4220 | 1280 | ||
| Escherichia coli JM101 | 562 | |||
| Staphylococcus aureus ST398 | 523796 | |||
| Experiment for Molecule Alteration |
Whole genome sequence assay; Allelic frequency measurement assay | |||
| Experiment for Drug Resistance |
Broth microdilution method assay | |||
| Mechanism Description | The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance. | |||
References
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