Molecule Information

General Information of the Molecule (ID: Mol00731)

• Name: Epidermal growth factor receptor/Protein Mdm4 (EGFR/MDM4) ,Homo sapiens
• Molecule Type: Protein
• Gene Name: EGFR/MDM4
• Gene ID: 1956; 4194
• Uniprot ID: EGFR_HUMAN/MDM4_HUMAN

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Clinical Trial Drug(s) 1 drug(s) in total

Carboxyamidotriazole orotate

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Glioblastoma [1]

• Resistant Disease: Glioblastoma [ICD-11: 2A00.02]
• Resistant Drug: Carboxyamidotriazole orotate
• Molecule Alteration: Structural mutation; Structural variation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: PI3K signaling pathway; Activation; hsa04151
• In Vivo Model: A retrospective survey in conducting clinical studies; Homo sapiens
• Experiment for Molecule Alteration: FISH assay; Whole-exome sequencing assay; Exome sequencing assay
• Experiment for Drug Resistance: Magnetic resonance imaging assay
• Mechanism Description: Indeed, EGFR and MDM4 FISH analysis of the patient-derived primary GBM cells from the second recurrence showed the presence of DMs, which are known to be resistant to targeted chemotherapies as previously reported.

References

• Ref 1: Longitudinal analysis of treatment-induced genomic alterations in gliomas. Genome Med. 2017 Feb 2;9(1):12. doi: 10.1186/s13073-017-0401-9.