Molecule Information

General Information of the Molecule (ID: Mol00364)

• Name: NUP98-DDX10 fusion protein type 1 (NUP98-DDX10 ) ,Homo sapiens
• Synonyms: PTSG_00124; NUP98-DDX10 fusion protein type 1
• Molecule Type: Protein
• Gene Name: PTSG_00124
• Gene ID: 16067821
• Sequence:
  MGRKGNKKQHVADAADADVKEEEVESTPTPQPTPSALPLEATANAGEWERLTHSDGTPLK
  LDERILTRLRAWKFDQMTPVQAACVPLFLEYKDVAAEAVTGSGKTLAFLIPAVEMLLRTP
  PKSRMAVGCIVLSPTRELAQQTHHVLSDLLKDSPLTHVLITGGKDAETDIVSMEKHGTNI
  IVATPGRLNDLIKRVPSLATNIKLLEVFVMDEADRLLDMGFKTTLNEILAVLPKQRRTGL
  FSATQTKEVELLVRAGLRNPVRVTVAVEDPEMFVHRCGRTARNGLDGNALLYLMPTEDEY
  VEFLKIRQVPMEEMDAITAAPSQFSAVRTHAANDRDIYEKGRLAFVSYIRSYREHKCNFL
  LKLSRLDLGMVANGFGLLDLPVMPELKKSKAAANFVPSDVDTSAITFKDKNREKQRQENL
  KRRGDRTSDPAAKRSKERQKQKNEAWSKQKERKKKKLARATKKQQQEDRKRKKMLENLLE
  TEQEWDELAREVRLRKQLKQGKITQDEFERLVGEDADPVMTM
• Uniprot ID: F2TVL2_SALR5

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Imatinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Chronic myeloid leukemia [1]

• Resistant Disease: Chronic myeloid leukemia [ICD-11: 2A20.0]
• Resistant Drug: Imatinib
• Molecule Alteration: Structural mutation; Structural variation
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: K562 cells; Blood; Homo sapiens (Human); CVCL_0004
• Experiment for Molecule Alteration: RT-PCR analysis
• Experiment for Drug Resistance: Western blot analysis with anti-CrkL antibody assay
• Mechanism Description: Collectively, these observations raise the possibility that NUP98/DDX10 might have played a role not only in disease progression but also in the acquisition of resistance to imatinib.

References

• Ref 1: Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia. Cancer Genet Cytogenet. 2005 Mar;157(2):104-8. doi: 10.1016/j.cancergencyto.2004.06.014.