Molecule Information

General Information of the Molecule (ID: Mol00154)

• Name: Ribosomal protein S6 (RPS6) ,Homo sapiens
• Synonyms: Phosphoprotein NP33; Small ribosomal subunit protein eS6; OK/SW-cl.2
• Molecule Type: Protein
• Gene Name: RPS6
• Gene ID: 6194
• Location: chr9:19375715-19380236[-]
• Sequence:
  MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
  FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
  IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
  TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
  TSKSESSQK
• Function: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
• Uniprot ID: RS6_HUMAN
• Ensembl ID: ENSG00000137154
• HGNC ID: HGNC:10429

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Trastuzumab

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Breast cancer [1]

• Sensitive Disease: Breast cancer [ICD-11: 2C60.3]
• Sensitive Drug: Trastuzumab
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: PI3K/AKT/mTOR signaling pathway; Inhibition; hsa04151
• In Vitro Model: SkBR3 cells; Breast; Homo sapiens (Human); CVCL_0033
• In Vitro Model: JIMT-1 cells; Breast; Homo sapiens (Human); CVCL_2077
• Experiment for Molecule Alteration: Western blot analysis; Luciferase reporter assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: miR129-5p might inhibit trastuzumab resistance through downregulating rpS6 in Her-2-positive breast cancer cells, thus inactivating the PI3k/Akt/mTOR/ rpS6 pathway.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Breast cancer [ICD-11: 2C60]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Breast tissue
• The Specified Disease: Breast cancer
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 6.31E-19; Fold-change: -2.03E-01; Z-score: -5.56E-01
• The Expression Level of Disease Section Compare with the Adjacent Tissue: p-value: 1.32E-02; Fold-change: -3.41E-01; Z-score: -5.63E-01

References

• Ref 1: MiR-129-5p Sensitizes the Response of Her-2 Positive Breast Cancer to Trastuzumab by Reducing Rps6. Cell Physiol Biochem. 2017;44(6):2346-2356. doi: 10.1159/000486122. Epub 2017 Dec 15.