Molecule Information

General Information of the Molecule (ID: Mol00078)
Name
Glutathione S-transferase P (GSTP1) ,Homo sapiens
Synonyms
GST class-pi; GSTP1-1; FAEES3; GST3
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Molecule Type
Protein
Gene Name
GSTP1
Gene ID
2950
Location
chr11:67583742-67586656[+]
Sequence
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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3D-structure
PDB ID
7XBA
Classification
Transferase/inhibitor
Method
X-ray diffraction
Resolution
2.83  Å
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
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Uniprot ID
GSTP1_HUMAN
Ensembl ID
ENSG00000084207
HGNC ID
HGNC:4638
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule with Structure Alteration
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Folfox protocol
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Colorectal cancer [ICD-11: 2B91.1] [1]
Sensitive Disease Colorectal cancer [ICD-11: 2B91.1]
 Disease Info 
Sensitive Drug Folfox protocol
 Drug Info 
Molecule Alteration Missense mutation
p.I105V (c.313A>G)
Wild Type Structure Method: X-ray diffraction Resolution: 1.40  Å
PDB: 2A2R
Mutant Type Structure Method: X-ray diffraction Resolution: 1.80  Å
PDB: 1PGT
   Download The Information of Sequence       Download The Structure File   
RMSD: 0.32
TM score: 0.99645
Amino acid change:
I105V
 : Wild Type Structure
 : Mutant Type Structure
  Mutation site(s) have been marked in red
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M
M
P
P
P
P
Y
Y
T
T
V
V
V
V
Y
Y
F
F
10
|
P
P
V
V
R
R
G
G
R
R
C
C
A
A
A
A
L
L
R
R
20
|
M
M
L
L
L
L
A
A
D
D
Q
Q
G
G
Q
Q
S
S
W
W
30
|
K
K
E
E
E
E
V
V
V
V
T
T
V
V
E
E
T
T
W
W
40
|
Q
Q
E
E
G
G
S
S
L
L
K
K
A
A
S
S
C
C
L
L
50
|
Y
Y
G
G
Q
Q
L
L
P
P
K
K
F
F
Q
Q
D
D
G
G
60
|
D
D
L
L
T
T
L
L
Y
Y
Q
Q
S
S
N
N
T
T
I
I
70
|
L
L
R
R
H
H
L
L
G
G
R
R
T
T
L
L
G
G
L
L
80
|
Y
Y
G
G
K
K
D
D
Q
Q
Q
Q
E
E
A
A
A
A
L
L
90
|
V
V
D
D
M
M
V
V
N
N
D
D
G
G
V
V
E
E
D
D
100
|
L
L
R
R
C
C
K
K
Y
Y
I
V
S
S
L
L
I
I
Y
Y
110
|
T
T
N
N
Y
Y
E
E
A
A
G
G
K
K
D
D
D
D
Y
Y
120
|
V
V
K
K
A
A
L
L
P
P
G
G
Q
Q
L
L
K
K
P
P
130
|
F
F
E
E
T
T
L
L
L
L
S
S
Q
Q
N
N
Q
Q
G
G
140
|
G
G
K
K
T
T
F
F
I
I
V
V
G
G
D
D
Q
Q
I
I
150
|
S
S
F
F
A
A
D
D
Y
Y
N
N
L
L
L
L
D
D
L
L
160
|
L
L
L
L
I
I
H
H
E
E
V
V
L
L
A
A
P
P
G
G
170
|
C
C
L
L
D
D
A
A
F
F
P
P
L
L
L
L
S
S
A
A
180
|
Y
Y
V
V
G
G
R
R
L
L
S
S
A
A
R
R
P
P
K
K
190
|
L
L
K
K
A
A
F
F
L
L
A
A
S
S
P
P
E
E
Y
Y
200
|
V
V
N
N
L
L
P
P
I
I
N
N
G
G
N
N
G
G
K
K
210
|
Q
Q
Click to Show/Hide the Structure
Experimental Note Identified from the Human Clinical Data
In Vitro Model Human colorectal carcinoma tissue N.A.
Mechanism Description The missense mutation p.I105V (c.313A>G) in gene GSTP1 cause the sensitivity of Folfox Protocol by drug inactivation by structure modification
References
Ref 1 Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinomaCancer Sci. 2010 Feb;101(2):530-5. doi: 10.1111/j.1349-7006.2009.01418.x. Epub 2009 Oct 28.

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