Molecule Information
General Information of the Molecule (ID: Mol00053)
| Name |
Catenin beta-1 (CTNNB1)
,Homo sapiens
|
||||
|---|---|---|---|---|---|
| Synonyms |
Beta-catenin; CTNNB; OK/SW-cl.35; PRO2286
Click to Show/Hide
|
||||
| Molecule Type |
Protein
|
||||
| Gene Name |
CTNNB1
|
||||
| Gene ID | |||||
| Location |
chr3:41194741-41260096[+]
|
||||
| Sequence |
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD L Click to Show/Hide
|
||||
| 3D-structure |
|
||||
| Function |
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
Click to Show/Hide
|
||||
| Uniprot ID | |||||
| Ensembl ID | |||||
| HGNC ID | |||||
| Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule with Structure Alteration
Drug Resistance Data Categorized by Drug
Preclinical Drug(s)
5 drug(s) in total
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | BAY1217389 | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of BAY1217389 by unusual activation of pro-survival pathway | ||||||||||||
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | MPI-0479605 | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of MPI-0479605 by unusual activation of pro-survival pathway | ||||||||||||
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | Mps-BAY2b | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of Mps-BAY2b by unusual activation of pro-survival pathway | ||||||||||||
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | Mps1-IN-1 | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of Mps1-IN-1 by unusual activation of pro-survival pathway | ||||||||||||
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | NTRC 0066-0 | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of NTRC 0066-0 by unusual activation of pro-survival pathway | ||||||||||||
Investigative Drug(s)
1 drug(s) in total
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | |||||||||||||
|
|
|||||||||||||
| Disease Class: Colorectal cancer [ICD-11: 2B91.1] | [1] | ||||||||||||
| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | ||||||||||||
| Sensitive Drug | NMS-P715 | ||||||||||||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
|||||||||||
| Wild Type Structure | Method: X-ray diffraction | Resolution: 2.20 Å | |||||||||||
| Mutant Type Structure | Method: X-ray diffraction | Resolution: 2.45 Å | |||||||||||
| Download The Information of Sequence | Download The Structure File | ||||||||||||
-
T
T
T
T
A
A
P
P
S
F
L
L
S
S
G
G
K
K
|
|||||||||||||
| Experimental Note | Revealed Based on the Cell Line Data | ||||||||||||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |||||||||
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | ||||||||||
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | ||||||||||
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | ||||||||||
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | ||||||||||
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | ||||||||||
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | ||||||||||
| In Vivo Model | Mouse xenograft model | Mus musculus | |||||||||||
| Experiment for Molecule Alteration |
Gene set analysis | ||||||||||||
| Experiment for Drug Resistance |
Cell proliferation assay | ||||||||||||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of NMS-P715 by unusual activation of pro-survival pathway | ||||||||||||
References
If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Yu.
